PAN Klark (US),ПАН Кларк (US),TSYU Khuavej (US),ЦЮ Хуавэй (US),DKHAL Pradip (US),ДХАЛ Прадип (US),CHEN Bo (US),ЧЭНЬ Бо (US),DZHANOLIO Diego (US),ДЖАНОЛИО Диего (US)
申请号：
RU2015143057
公开号：
RU0002708314C2
申请日:
2014.03.10
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: biochemistry.SUBSTANCE: invention relates to biochemistry. Described is an isolated antibody or antigen-binding fragment thereof for delivering a cytotoxin comprising a CH1 IgG domain, where the CH1 IgG domain contains an asparagine residue in the amino acid position 114 in accordance with the Kabat numbering, where the side chain of the said asparagine residue is linked to the glycan. Also described is an isolated antibody or its antigen-binding fragment for the delivery of a detection agent containing a CH1 IgG domain, where the CH1 domain of the IgG contains an asparagine residue in the amino acid position 114 in accordance with the Kabat numbering, where the side chain of the said asparagine residue is linked to the glycan. Also described is an isolated antibody or its antigen-binding fragment for the delivery of a cytotoxin containing a CH1 domain of IgG, where the CH1 domain of the IgG contains an asparagine residue in the amino acid position 114 in accordance with the Kabat numbering, where the side chain of said asparagine residue is bound to glycan by β-glycosylamide linkage and where glycan is linked to detection agent. Also described is an isolated antibody or antigen-binding fragment thereof for the delivery of a detection agent containing a CH1 IgG domain, where the CH1 IgG domain contains the asparagine residue in the amino acid position 114 in accordance with the Kabat numbering, where the side chain of said asparagine residue is bound to glycan by β-glycosylamide linkage and where glycan is linked to cytotoxin. Also disclosed is an isolated antibody or an antigen-binding fragment thereof for cytotoxin binding, containing an CH1 domain of IgG, wherein the CH1 domain of IgG contains a free asparagine residue in the position of amino acid 114 in accordance with the Kabat numbering. Disclosed is an isolated antibody or antigen-binding fragment thereof for binding a detection agent containing a CH1 IgG domain, wherein the CH1 domain of the IgG cont
