РОЛЛИНС Скот (US),АЛЬВАРЕЗ Ричард (US),РОТЕР Рассел (US),КАВАР Зиад С. (US),МАКИВЕР Роджер П. (US)
申请号：
RU2013133412/10
公开号：
RU2013133412A
申请日:
2011.12.21
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The selected antibody or its binding fragment, which specifically bind to the conformational epitope of P-selectin, and this conformational epitope is within the amino acid residues at positions 1-35 in SEQ ID NO: 1.2. The isolated antibody or its binding fragment according to claim 1, where the conformational epitope is within the amino acid residues at positions 4-23 in SEQ ID NO: 1.3. The isolated antibody or its binding fragment according to claim 2, where the conformational epitope includes amino acid residues at positions 4, 14, 17, 21 and 22 in SEQ ID NO: 1.4. The isolated antibody or its binding fragment according to claim 2, where the amino acid residues at positions 4, 14, 17, 21 and 22 are H, I, K, N and R, respectively. The isolated antibody or its binding fragment according to claim 4, where the binding is broken when one or more amino acid residues at positions 4, 14, 17, 21 and 22 is replaced by N, N, V, R or H, respectively. The isolated antibody or its binding fragment according to claim 1, with the ability to block the binding of glycoprotein ligand-1 P-selectin (PSGL-1) to P-selectin. The isolated antibody or its binding fragment according to claim 1, additionally having the ability to cause dissociation of the previously formed complex P-selectin / PSGL-1.8. The isolated antibody or its binding fragment according to claim 1, having the ability to block the function of P-selectin by inhibiting the binding of activated endothelial cells to white blood cells, lymphocytes, sickle-shaped red blood cells and / or platelets. The isolated antibody or its binding fragment according to claim 1, having the ability to block the function of P-selectin by inhibiting the binding1. Выделенное антитело или его связывающий фрагмент, которые специфически связываются с конформационным эпитопом P-селектина, причем этот конформационный эпитоп находится в пределах аминокислотных остатков в положениях 1-35 в SEQ ID NO:1.2. Выделенное антитело или его связывающий фраг
