The present invention provides a multi-layer capsule and a manufacture method thereof. Different materials are filled in sequence into one capsule to form a multiple layered structure. The design of such a structure and a method of filling prevents the diffusion and/or reaction of materials of adjacent layers.本發明提供一種多層填充膠囊及其製造方法,將不同配方的充填物分次充填於一膠囊中,造成一含多層結構的膠囊,此種結構使得各充填物中之成份不會產生物質交換的現象。810...膠囊以蓋體與本體結合的狀態收容於進料斗820...將由進料斗取出的膠囊進行方向限制830...將膠囊之蓋體從本體分離840...排除分離不良之膠囊及本體有缺陷之膠囊850...充填第一均質物855...冷卻第一均質物860...充填阻隔層865...冷卻阻隔層870...充填第二均質物875...冷卻第二均質物880...結合蓋體與本體890...排出膠囊,並排除不填充或填充不完全之膠囊