CUMMING, JOHN,FAULL, ALAN WLLINGTON,WATERSON, DAVID
申请号：
PE0012292011
公开号：
PE00822012A1
申请日:
2009.12.14
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a carboxamide derivative Compound such as 4 - [(2R) - 2 - 4 - tert - butilpiperazina carbonyl] - N - (4 - chlorine - 3-fluorophenyl) - carboxamide piperazine - 1, 4 - [(2R) - 2 - 4 - tert - butilpiperazina carbonyl] - N - [3 - (trifluoromethyl) phenyl] piperazine - carboxamide - 1, 4 - [(2R) - 2 - 4 - tert - butilpiperazina carbonyl] - N - (3 - Clor Ofenil) piperazine - 1 - carboxamide, among others. It also relates to a Pharmaceutical composition.These compounds are ccr2b Receptor Antagonists and are useful in the treatment of inflammatory diseases and \/ or neuropathic painREFERIDA A UN COMPUESTO DERIVADO DE CARBOXAMIDA TAL COMO 4-[(2R)-4-TERC-BUTILPIPERAZINA-2-CARBONIL]-N-(4-CLORO-3-FLUOROFENIL)PIPERAZINA-1-CARBOXAMIDA, 4-[(2R)-4-TERC-BUTILPIPERAZINA-2-CARBONIL]-N-[3-(TRIFLUOROMETIL)FENIL]PIPERAZINA-1-CARBOXAMIDA, 4-[(2R)-4-TERC-BUTILPIPERAZINA-2-CARBONIL]-N-(3-CLOROFENIL)PIPERAZINA-1-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR CCR2b Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y/O DOLOR NEUROPATICO
