THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
RAMUNAS, JOHN,YAKUBOV, EDUARD,BLAU, HELEN M.,COOKE, JOHN
申请号：
CA2902237
公开号：
CA2902237A1
申请日:
2014.02.22
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds and compositions and instructions for use.
