MOREAU ALAIN CANADA,AKOUME NDONG MARIE YVONNE CANADA
申请号：
IN1403/KOLNP/2011
公开号：
IN299584B
申请日:
2009.10.13
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Methods for diagnosing a predisposition to developing a scoliosis (e g, adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protem-coupled receptor activity are described The methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand If the impedance is higher in the presence of the test compound when compared to in the absence of the test compound, then the test compound is useful in treating the scoliosis. WO2010040234A1
