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Electrified compositions for determining the risk of developing adolescent idiopathic scoliosis through the use of GI protein receptor
专利权人:
CHU Sainte-Justine
发明人:
Alain Moreau,Marie-Yvonne Akoume Ndong
申请号:
US14804225
公开号:
US10620222B2
申请日:
2015.07.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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