Longqin Hu,Sadagopan Magesh,Lin Chen,Timothy Lewis,Ben Munoz,Lili Wang
申请号：
US15718987
公开号：
US10106502B2
申请日:
2017.09.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimers, and Parkinsons. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.
