Jean Herman,Thierry Louat,Qiuya Huang,Bart Vanderhoydonck,Mark Waer,Piet Herdewijn
申请号：
US14343416
公开号：
US20140294870A1
申请日:
2012.09.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds that bind to phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) and inhibit the binding of PI4KIIIβ to its substrate and/or inhibit PI4KIIIβ activity may be used in the treatment and/or prevention of an autoimmune or inflammatory disorder, or organ or cell transplant rejection. A new assay for identifying compounds for use in treating and/or preventing those pathological conditions, which comprises measuring the inhibition of PI4KIIIβ activity, is also disclosed.
