The present invention provides the methods for the treatment of depression, such as the individual of major depressive disorder (MDD). The present invention also provides methods to determine individually the suffer from depression possible treatment effect for responding favorably or undergoing enhancing and vortioxetine responses processing. It is optionally wherein each also to receive depression and/or MDD the present invention also provides treatment cognitive impairment individual. Determining that individual may be responded with cognitive impairment the present invention also provides method favorably or undergoes the treatment effect of enhancing and vortioxetine responses to handle. The method includes to determine that there are polymorphisms, collagen type XXVI, (COL26A1) genes of α 1 and/or calcium channel, it is pressure-sensitive, L-type, the individual of α 1C subunits (CACNA1C) gene and/or CUB and (CSMD1) gene of sushi multiple domain 1 and/or (ZSCAN4) gene of zinc finger proteins 494 and/or (ZNF551) gene of zinc finger proteins 551 and/or dymeclin (DYM) gene and LINC00348 genes and/or FOXL2NB genes and/or intergenic region.
