6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block

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专利权人:

MERCK SHARP & DOHME B.V.

发明人:

申请号：

BE2008C047

公开号：

BE2008C047I2

申请日:

2008.12.10

申请国别(地区):

BE

年份:

2019

代理人:

摘要：

Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8； R is (C1-6)alkylene, optionally substituated with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p-； o and p are independently 0-4； X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2-CH2-O)q-H, OH or tetrazol-5-yl； R1 is H or (C1-3)alkyl； R2 is carboxyphenyl； q is 1-3； or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.

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