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6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
专利权人:
MERCK SHARP & DOHME B.V.
发明人:
申请号:
BE2008C047
公开号:
BE2008C047I2
申请日:
2008.12.10
申请国别(地区):
BE
年份:
2019
代理人:
摘要:
Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6)alkylene, optionally substituated with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p-; o and p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2-CH2-O)q-H, OH or tetrazol-5-yl; R1 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.
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