6-mercapto-cyclodextrin derivatives:reversal agents for drug-induced neuromuscular block

• 收藏
• 分享

专利权人:

Jonathan Bennett;Mingiang Zhang;Ronald Palin

发明人:

Mingiang Zhang,Ronald Palin,Jonathan Bennett

申请号：

US13432742

公开号：

USRE044733E1

申请日:

2012.03.28

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8； R is (C1-6)alkylene, optionally substituated with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p—； o and p are independently 0-4； X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2—CH2—O)q—H, OH or tetrazol-5-yl； R1 is H or (C1-3)alkyl； R2 is carboxyphenyl； q is 1-3； or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/