KIM, JIN CHEUL,金辰哲,金辰哲,KIM, JAE HO,金载镐,金載鎬,YOON, EUN JIN,尹银镇,尹銀鎮,KIM, YONG IL,金用镒,金用鎰,PARK, JAE HYUN,朴宰贤,朴宰賢,WOO, JONG SOO,禹锺守,禹鍾守
申请号：
TW101142820
公开号：
TW201328727A
申请日:
2012.11.16
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention relates to an oral complex formulation comprising omega-3 fatty acid or its derivatives encapsulated in a hard or soft capsule containing sorbitol and sorbitan, as well as an HMG-CoA reductase inhibitor. The formulation of the present invention comprising omega-3 fatty acid encapsulated with sorbitol and sorbitan provides better prevention related materials from being formed, leading to improved long-term storage stability. The oral complex formulation of the present invention also can raise the serum HDL-cholesterol level, while reducing both LDL-cholesterol and TG levels. The oral complex formulation of the present invention is useful for treatment of hyperlipidemia.本發明係有關於一種口服複合調配物,其包含封裝於含有山梨醇及山梨醇酐之一硬式或軟式膠囊內之ω-3脂肪酸或其衍生物,與一HMG-CoA還原酶抑制劑。包含以山梨醇及山梨醇酐封裝之ω-3脂肪酸的本發明調配物提供較佳地避免相關物質被形成,導致改良之長期貯存穩定性。本發明之口服複合調配物亦可提高血清HDL-膽固醇量,同時降低LDL-膽固醇及TG二者之量。本發明之口服複合調配物可用於治療高血脂症。
