INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);REGENERON PHARMACEUTICALS INC.;YALE UNIVERSITY
发明人:
Murphy, Andrew,Flavell, Richard,Manz, Markus,Rongvaux, Anthony,Strowig, Till,Willinger, Tim,Stevens, Sean,Yancopoulos, George
申请号：
NZ70495713
公开号：
NZ704957A
申请日:
2013.09.06
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
A genetically modified mouse comprising in its genome a nucleic acid encoding human M-CSF, a nucleic acid encoding human IL-3, a nucleic acid encoding human GM-CSF, a nucleic acid encoding human SIRPA and a nucleic acid encoding human TPO, wherein each of the nucleic acids encoding human M-CSF, human IL-3, human GM-CSF, human SIRPA and human TPO is operably linked to a promoter, and wherein the mouse expresses human M-CSF polypeptide, human IL-3 polypeptide, human GM-CSF polypeptide, human SIRPA polypeptide and human TPO polypeptide.
