BACHYNSKY, MARIA OKSANA,INFELD, MARTIN HOWARD,RASHED, MOHAMMAD,SHAH, NAVNIT HARGOVINDAS
申请号：
MYPI 20091372
公开号：
MY145637A
申请日:
2007.09.26
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
THERE IS PROVIDED A FILM COATED PHARMACEUTICAL COMPOSITION COMPRISING 5-DEOXY-5-FLUORO-N- [(PENTYLOXY)-CARBONYL]-CYTIDINE (CAPECITABINE) AND AT LEAST ONE DISINTEGRANT SELECTED FROM THE GROUP COMPRISING OF CROSPOVIDONE (PARTICLE SIZE <15-400 ), CROSCARMELLOSE SODIUM, SODIUM STARCH GLYCOLATE, LOW- SUBSTITUTED HYDROXYPROPYLCELLULOSE, PHARMABURST C OR ANY COMBINATION OF THESE, TOGETHER WITH OTHER PHARMACEUTICALLY ACCEPTABLE EXCIPIENTS TO FORM A RAPIDLY DISINTEGRATING TABLET. THIS TABLET DISINTEGRATES IN WATER AT 37OC IN A USP DISINTEGRATION APPARATUS IN LESS THAN 2 MINUTES, PREFERABLY 1 MINUTE AND HAVE A HARDNESS OF 8-13 STRONG COBB-UNITS.
