Olbrich, Carsten,Bunte, Thomas,Winter, Jonas,Peters, Jörg,Trill, Thomas
申请号：
NZ70789513
公开号：
NZ707895A
申请日:
2013.11.05
申请国别(地区):
NZ
年份:
2019
代理人:
摘要：
The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen binding domains and are particularly suitable for subcutaneous administration. In particular, a liquid pharamaceutical composition comprising: a polypeptide, TRIS and phosphate, the polypeptide comprising the amino acid sequence reproduced in SEQ ID NO: 8, characterized in that the composition contains the polypeptide in a concentration of from 0.5 µg/ml to 3.0 mg/ml, that the composition contains 100 mM TRIS and 50 mM phosphate, that the pH of the composition is about 6.0 and that the composition contains 0.04% polysorbate 80. The invention provides liquid compositions which minimize the formation of unwanted polypeptide aggregates (dimers and/or multimers). The present invention further provides a method of minimizing the aggregation of polypeptides having antigen binding domains in liquid compositions.
