INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YONSEI UNIVERSITY
发明人:
HWANG, KI CHUL,황기철,JANG, YANG SOO,장양수
申请号：
KR1020120103005
公开号：
KR1020130030329A
申请日:
2012.09.17
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A novel low molecular compound is provided to induce differentiation of mesenchymal stem cells into vascular endothelial cells.CONSTITUTION: A compound is denoted by chemical formula 1. In chemical formula 1, X is a carbon, oxygen, or nitrogen atom R1 is hydrogen or a C1-C6 alkyl group R2 is hydrogen, a nitro group, an acetyl group, or an amino group R3 is hydrogen, a hydroxyl group, C1-C6 alkoxy group, a nitro group, an acetamide group, or halogen, phenyl, or pyrazolyl-substituted or non-substituted benzamide and R4 is hydrogen, hydroxyl-substituted C1-C6 alkyl, an acetyl group, halogen, a nitro group, an amino group, a halogen-substituted or non-substituted acetamide group, a picolinamide, a thiophenecarboxamide group, a carboxy group, or substituted or non-substituted benzamide group.COPYRIGHT KIPO 2013본 발명은 중간엽 줄기세포의 혈관내피세포로의 분화 유도를 위한 몰포린/피페라진기를 함유하는 아마이드 유도체 및 이의 의약적 용도를 제공한다. 상기 아마이드 유도체로 처리된 중간엽 줄기세포는 혈관내피세포로 특이적으로 분화 유도되므로 이를 이용하면 풍선확장술 등에 의한 혈관내피세포 손상과 같은 혈관질환을 효과적으로 치료할 수 있게 된다.
