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Differentiation induction from pluripotent stem cells to mesodermal progenitor cells and blood vascular progenitor cells
专利权人:
国立大学法人京都大学
发明人:
中畑 龍俊,齋藤 潤,丹羽 明,太田 諒,鈴木 直也
申请号:
JP2015142734
公开号:
JP6646311B2
申请日:
2015.07.17
申请国别(地区):
JP
年份:
2020
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide a method for producing mesodermal progenitor cells from pluripotent stem cells and a method for producing blood vessel progenitor cells from mesodermal progenitor cells.SOLUTION: The method of the present invention can produce mesodermal progenitor cells by subjecting pluripotent stem cells to adhesion culture in a culture medium containing BMP, VEGF, and GSK-3β inhibitors on a culture device coated with laminin 511 or a fragment thereof. Blood vessel progenitor cells can be produced by further subjecting the mesodermal progenitor cells produced by such a method to adhesion culture in a culture medium containing VEGF, SCF, bFGF, and TGF-β inhibitors.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2017,JPO&INPIT
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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