THE PRESENT INVENTION RELATES TO A COMBINATION COMPRISING: (I) A RENIN INHIBITOR, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； (II) A NEUTRAL ENDOPEPTIDASE (NEP) INHIBITOR, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； AND OPTIONALLY AT LEAST ONE THERAPEUTIC AGENT SELECTED FROM THE GROUP CONSISTING OF (A) A DIURETIC, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； AND (B) AN ANGIOTENSIN II RECEPTOR BLOCKER (ARB), OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF； FOR THE PREVENTION OF, DELAY THE ONSET OF AND/OR TREATMENT OF A DISEASE OR A CONDITION MEDIATED BY ANGIOTENSIN II AND/OR NEP ACTIVITY, WHICH METHOD COMPRISES ADMINISTERING TO A WARM-BLOODED ANIMAL, IN NEED THEREOF, A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMBINATION OF THE PRESENT INVENTION.
