Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors

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专利权人:

Merck Patent GmbH

发明人:

Dirk Finsinger,Margarita Wucherer-Plietker,Beatrix Blume

申请号：

US15105436

公开号：

US09688684B2

申请日:

2014.11.26

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention relates to tetrahydro-tetrazolo[1,5-a]pyrazine compounds of formula (I), wherein R1 denotes —R3, —CH2—R3 or —CO—R3； R2 denotes Ar2, Hetar2 or C3-7-cycloalkyl； and R3 denotes Ar3, Hetar3 or C3-7-cycloalkyl. These compounds are useful for inhibiting the retinoid-related orphan receptor γ (ROR γ, ROR-gamma) and for the prevention and/or treatment of medical conditions affected by ROR γ activity such as rheumatoid arthritis, multiple sclerosis, psoriasis, ulcerative colitis, asthma, autoimmune hepatitis or type 1 and type 2 diabetes.

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