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Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
专利权人:
Merck Patent GmbH
发明人:
Dirk Finsinger,Margarita Wucherer-Plietker,Beatrix Blume
申请号:
US15105436
公开号:
US09688684B2
申请日:
2014.11.26
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to tetrahydro-tetrazolo[1,5-a]pyrazine compounds of formula (I), wherein R1 denotes —R3, —CH2—R3 or —CO—R3; R2 denotes Ar2, Hetar2 or C3-7-cycloalkyl; and R3 denotes Ar3, Hetar3 or C3-7-cycloalkyl. These compounds are useful for inhibiting the retinoid-related orphan receptor γ (ROR γ, ROR-gamma) and for the prevention and/or treatment of medical conditions affected by ROR γ activity such as rheumatoid arthritis, multiple sclerosis, psoriasis, ulcerative colitis, asthma, autoimmune hepatitis or type 1 and type 2 diabetes.
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