TETRAHYDROTETRAZOLO[1,5-A]PYRAZINES UTILISEES COMME INHIBITEURS DU ROR-GAMMA

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专利权人:

MERCK PATENT GMBH

发明人:

FINSINGER, DIRK,WUCHERER-PLIETKER, MARGARITA,BLUME, BEATRIX

申请号：

CA2934378

公开号：

CA2934378A1

申请日:

2014.11.26

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention relates to tetrahydro-tetrazolo[l,5-a]pyrazine compounds of formula (I), wherein R1 denotes -R3, -CH2-R3 or -CO-R3； R2 denotes Ar2, Hetar2 or C3-7-cycloalkyl； and R3 denotes Ar3, Hetar3 or C3-7-cycloalkyl. These compounds are useful for inhibiting the retinoid-related orphan receptor ? (ROR ?, ROR-gamma) and for the prevention and/or treatment of medical conditions affected by ROR ? activity such as rheumatoid arthritis, multiple sclerosis, psoriasis, ulcerative colitis, asthma, autoimmune hepatitis or type 1 and type 2 diabetes.

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