Devices and methods are described for electrolytically, ultrasonically, or both electrolytically and ultrasonically disrupting debris on an eyelid margin. A device includes an eyelid contacting portion having at least a first electrode, a second electrode, and a power supply electrically coupled to at least one of the first and second electrodes. The eyelid contacting portion may optionally have a shelf separating an upper portion from a lower portion with electrodes on the upper and lower portions. The eyelid contacting portion may optionally include at least one channel with electrodes. The device may optionally include an ultrasonic driver. Another device includes an ultrasonic driver but no electrodes. A method contacts debris on an eyelid margin with a first electrode and contacting a surface of an eyelid with a second electrode and supplying electrical energy to one of the first or second electrodes to disrupt the debris. Another method applies ultrasonic energy to the eyelid margin to disrupt debris on the eyelid margin.
