METHOD FOR DETERMINING INDIVIDUAL ACTIVITY OF 131-IODINE FOR RADIOIODINE THERAPY OF THYROTOXICOSIS AND PREDICTION OF TIME FOR ACHIEVING A SAFE LEVEL OF 131-IODINE ACTIVITY IN THE PATIENT'S BODY AFTER ADMINISTERING INDIVIDUAL 131-IODINE ACTIVITY
Trukhin Aleksej Andreevich (RU),Трухин Алексей Андреевич (RU),Rumyantsev Pavel Olegovich (RU),Румянцев Павел Олегович (RU),Dedov Ivan Ivanovich (RU),Дедов Иван Иванович (RU),Melnichenko Galina Afanase
申请号：
RU2019145354
公开号：
RU0002722568C1
申请日:
2019.12.31
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine.SUBSTANCE: group of inventions refers to medicine, namely to endocrinology, radiology, therapy, and can be used to determine individual activity of 131-iodine for radioiodine therapy of thyrotoxicosis, as well as predicting time to achieve a safe level of activity of 131-iodine in the patient's body after administering individual activity of 131-iodine. Method for determining individual activity of 131-iodine for radioiodine therapy of thyrotoxicosis involves determining the volume of (k) sections of thyroid tissue (Vk, [ml]), specific index of thyroid capture of 99mTc-pertechnetate (I, [%]), distribution of thyroid capture of 99mTc-pertechnetate over sections of thyroid tissue (Rk, [%]), as well as determination of maximum and integral thyroid capture of 131-iodine. Working solution is introduced orally in volume of 5 to 10 ml with activity content (A0) of 131-iodine from 5 to 10 MBq. Further, two dosimeters are placed on the patient's body and made with possibility of periodic recording of gamma-radiation power up to 2 mSv/h and autonomous operation up to 5 days: the first – at the level of the thyroid gland, the second – at the level of bladder. Gamma-power of is continuously recorded for 2–5 days, where j is the number of the dosimeter, p is the number of the registered value after a certain time interval from range of 2–15 minutes, with preservation of the registered data in the dosimeter memory. Thereafter, these values are converted into activity values of 131-iodine to obtain data sets A1p and A2p with subsequent averaging of data for each hour of measurements to obtain arrays where i is number of hour after working solution introduction. Further, the therapeutic activity of the thyroid tissue is determined: if the specific index of the thyroide capture of 99mTc-pertechnetate is less than 0.5 %/ml by formula the specific index of the thyroid capture of 99mTc-pertechnetate is more than 0.5 %/ml by formula where is a dose accumulation fact
