WANG YIFEI,XING GUOWEN,JU HUAIQIANG,LIN WENHUI,QIAN CHUIWEN,XIA MIN,ZHOU XIAOPING,ZHANG MEIYING
申请号：
IN4127/DELNP/2013
公开号：
IN2013DN04127A
申请日:
2013.05.08
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Disclosed are an Hsp90 inhibitor and a preparation method and use thereof The Hsp90 inhibitor is 2-(4-(3-acetylcamitineacyloxy) cyclohexylamino)-4-(l-(3,6,6- trimethyl-4-oxy-4,5,6,7-tetrahydroindazole)) benzamide. The Hsp90 inhibitor has good water solubility and high bioavailability, and can effectively inhibit the proliferation of cancer cells, such as leukemia, cervical cancer, breast cancer, human laryngeal 10 epithelial carcinoma or malignant melanoma, and can effectively inhibit the activity of herpes simplex virus, and the maximal non-toxic concentration of the Hsp90 inhibitor on normal cells is a high, and the Hsp90 inhibitor only has specific inhibition effect on cancer cells.
