MIRANDA, LESLIE,LONG, JASON,HONG, FANG,TSAO - HARRINGTON, ESSA HU,CHONG, SU,CHEN, IRWIN
申请号：
ARP180101446
公开号：
AR111842A1
申请日:
2018.05.31
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
The peptides they provide are linked to human PAC1. These PAC1 antagonistic peptides can be used in many PAC1 related diseases, including treatment and / or prevention of headache, including severe migraine. Requirement 1: a formulated peptide (1),o una sal farmac uticamente aceptable del mismo X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X (1)Where x830404 is Gly, yes, yes, yes,Ala Met Gly-Met-[PRA], or if x83099 is Cys or x1, X1 is Cys, if xi83099 is ser, THR, or absent, X2 is ASP, Glu, or residual amino acid, or absent, X3 is ala, pro, Ser, [AIB], or residual amino acid hydrate, or absent, xi8308 is th, Ser, Val, Tyr, or neutral, hydrofluoro or amino acid, or difluoro residue； 1. If X1 is Cys or X 83099, then X1 is or is not, then XL 8310es Lys, [CIT], his, Arg or other basic residues of amino acids or Gln, ASN, Phe or other neutral residues, amino acids or glucose or other amino acid residues, or XL 8311es Phe, Tyr, his, or a neutral hydrate is missing；o est ausente X es Lys Arg o un residuo b sico de amino cido o est ausente X es Lys Arg o un residuo b sico de amino cido o est ausente X es Ala Cys Gly Leu Gln Val o un residuo neutral de amino cido o est Tyr or other neutral amino acid, or Asp, [Cit], or other neutral residue or amino acid, or His, Lys or other basic amino acid residue, or absent, X¹⁶ is Lys, Arg, His, or other basic residue of amino acid or Phe, Ile, Leu, [Aib], Gln, Met, Thr, Val, Gly, Asn, [Pra], Trp, Tyr or other neutral residue or [hGlu] amino acid, or is absent, X¹⁷ is Ala , Gln, [Aib], Phe, Ile, Leu, Ser, Val, Trp, Tyr, Thr or other neutral amino acid residue, or [Cit], Lys, Arg, or other basic amino acid residue or Asp, or other residue amino acid or is absent, X¹⁸ is Ala, Leu, [Aib], [Pra], or other neutral amino acid residue,or Glu or another acidic amino acid residue or Lys, or other basic amino acid residue, or is absent, X¹⁹ is His or another basic amino acid residue or Ala, Phe, Ile, Leu,
