The present disclosure provides systems and methods for an adjustable bed. The bed includes a frame mounted to a subframe. The frame is movable length-wise with respect to the subframe. The subframe includes a head lift, a foot lift, or both a head lift and a foot lift, for adjusting a vertical position of the frame with respect to the subframe. When wheels of the frame mount the head lift, the foot lift, or both, the frame assumes an orientation that is inclined with respect to the subframe. The orientation may be inclined positively, inclined negatively or inclined flat with respect to the subframe. Using the lifts, the bed may assume a zero-gravity inclination, in which the users heart is at the same level as the users feet. An actuator and controls may be used to adjust a position of the frame.