SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;ZHEJIANG UNIVERSITY
发明人:
Tao Liu,Jia Li,Yongzhou Hu,Yubo Zhou,Xiaowu Dong,Anhui Gao,Pinrao Song,Peipei Wang,Lexian Tong,Xiaobei Hu,Mingbo Su
申请号：
US16348502
公开号：
US20190375727A1
申请日:
2017.11.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A 2-substituted aromatic ring-pyrimidine derivative as shown in a general formula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chk1 kinase inhibitory activity and are promising Chk1 inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.
