HUMPHREYS DAVID PAUL,LIGHTWOOD DANIEL JOHN,TYSON KERRY LOUISE,KNIGHT DAVID EDWARD ORMONDE,HERVÉ KARINE JEANNINE MADELEINE,COMPSON JOANNE ELIZABETH,PAGE MATTHEW JON TIMOTHY,PAYNE ANDREW CHARLES,FISHER
申请号：
NZ62329312
公开号：
NZ623293A
申请日:
2012.09.10
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a pharmaceutical composition comprising a monoclonal antibody suitable for reducing the duration and/or severity of diarrhoea or morbidity and/or mortality in a patient with Clostridium difficile infection or at risk of said infection wherein the antibody is specific to: antigen Clostridium difficile toxin A (TcdA) and binds 3 or more times in the range S1827-D2249 or G2205-R2608 of SEQ ID NO: 171 with an EC50 in the range 0.1 to 10 ng/ml when toxin is used at an LD80 or higher.
