Alessia Fornoni;Sandra Merscher-Gomez;George William Burke
发明人:
Alessia Fornoni,George William Burke,Sandra Merscher-Gomez
申请号：
US13879892
公开号：
US10052345B2
申请日:
2011.10.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Assays, methods and kits for predicting a subject's (e.g., human) risk of primary glomerulopathy, secondary glomerulopathy or recurrence (e.g., post-transplant recurrence) of any glomerular disease include examining cells for the presence or absence of cytoskeletal disruptions or rearrangements and examining cells for modulation of expression and/or activity of markers such as SMPDL-3b. Assays for predicting if a diabetic subject will develop kidney disease or a patient with FSGS will develop recurrent disease after transplant also include examining cells for the presence or absence of cytoskeletal disruptions or rearrangements and examining cells for modulation of expression and/or activity of markers such as SMPDL-3b. Also described herein are compositions and methods for treating and preventing the afore-mentioned disorders.
