Kent D. Taylor;Jerome I. Rotter;Stephan R. Targan;Charles O. Elson
发明人:
Kent D. Taylor,Jerome I. Rotter,Charles O. Elson,Stephan R. Targan
申请号：
US12599549
公开号：
US08153443B2
申请日:
2008.05.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation.
