PROBLEM TO BE SOLVED: To provide a composition effective for treating edema, ischemia, blood vessel diseases related to them, particularly, diabetic retinopathy, retinopathy of prematurity, macular degeneration related to age and glaucoma by stabilizing blood vessel walls to prevent blood leakage and helping growth of normal blood vessels, in the new formation and retainment of blood vessels.SOLUTION: The composition includes peptide comprising an Xaa-Gly-Asp sequence as an active constituent; wherein, Xaa amino acid denotes Arg or Lys.【課題】血管の新生及び保持において、血管壁を安定化して血液漏れを防ぎ、正常な血管の成長を助けることにより、浮腫及び虚血、並びにこれに関する血管疾患、特に糖尿病性網膜症、未熟児網膜症、年齢関連黄斑変性症、緑内障の治療に有効な組成物の提供。【解決手段】Xaa-Gly-Asp配列を含むペプチドを有効成分とする組成物。ここでXaaアミノ酸はArg又はLysである。【選択図】なし