University of Massachusetts;The Jackson Laboratory
发明人:
Shultz, Leonard D.,Verma, Mohit Kumar,Greiner, Dale L.,Brehm, Michael A.
申请号：
AU2016280105
公开号：
AU2016280105A1
申请日:
2016.06.16
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention relates generally to genetically modified non-human animals and immunodeficient non-human animals characterized by restored complement-dependent cytotoxicity, as well as methods and compositions for assessment of therapeutic antibodies in the genetically modified immunodeficient non- human animals. In specific aspects, the present invention relates to immunodeficient non-obese diabetic (NOD), A/J, A/He, AKR, DBA/2, NZB/BIN, B10.D2/oSn and other mouse strains genetically modified to restore complement-dependent cytotoxicity which is lacking in the unmodified immunodeficient mice. In further specific aspects, the present invention relates to NOD.Cg-
