Compositions and Methods of Treatment of Corneal Endothelium Disorders

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专利权人:

发明人:

Ula V. Jurkunas

申请号：

US14986253

公开号：

US20160175380A1

申请日:

2015.12.31

申请国别(地区):

US

年份:

2016

代理人:

摘要：

This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.

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