THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;UWM RESEARCH FOUNDATION, INC.
发明人:
ALEXANDER E. ARNOLD,CHARLES W. EMALA,DOUGLAS C. STAFFORD,GLORIA FORKUO,GUANGUAN LI,JAMES M. COOK,MICHAEL RAJESH STEPHEN,RAJWANA JAHAN,REVATHI KODALI
申请号：
BR112019003065
公开号：
BR112019003065A2
申请日:
2017.08.16
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
pyrrolobenzodiazepines target the gabaa alfa-4 and alpha-5 receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. The compounds selectively divide into the peripheral compartment and reduce the effects on snc.as pirrolobenzodiazepinas têm como alvo os receptores gabaa alfa-4 e alfa-5 para o uso no tratamento de hiper-responsividade das vias respiratórias e inflamação na asma. os compostos se dividem seletivamente no compartimento periférico e reduzem os efeitos no snc.
