PROBLEM TO BE SOLVED: To provide a novel COX-2 inhibitor, a hair tonic containing it, and a hair restoration method.SOLUTION: The invention relates to a COX-2 inhibitor containing a pyroligneous mandarin orange extract as an active ingredient, a hair tonic containing the inhibitor, and a composition containing the hair tonic, as well as a hair restoration method for non-human animals using them.COPYRIGHT: (C)2016,JPO&INPIT【課題】本発明によれば、新規なCOX-2阻害剤、それを含有する育毛剤および育毛方法が提供される。【解決手段】木酢みかん抽出物を有効成分とするCOX-2阻害剤、該阻害剤を含有する育毛剤および該育毛剤を含有する組成物ならびにそれらを用いたヒト以外の動物の育毛方法。【選択図】図2