ISOLATED MONOCLONAL ANTIBODY OR AN ANTIGEN-BINDING PORTION OF THE SAME, COMPOSITION, IMMUNOCATED, ISOLATED NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST CELL FOR PREPARING A CIRCULAR ANCLE4 MODULES CELL, AND TO STIMULATE MOBILIZATION OF CD34 + BODY BODY CELLS FOR PERIPHERAL BLOOD IN AN INDIVIDUAL.
MICHELLE KUHNE,PETER BRAMS,DAWN M. TANAMACHI,JOSEPHINE M. CARDARELLI,ALAN KORMAN
申请号：
BRPI0718197
公开号：
BRPI0718197A2
申请日:
2007.10.01
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.
