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Human antibodies that bind to CD19 and uses thereof
专利权人:
メダレックス・リミテッド・ライアビリティ・カンパニー
发明人:
キング デビッド ジョン,ラオ‐ナイク チェタナ,パン チン,カーダレリー ジョセフィーン,ブランセット ダイアン
申请号:
JP2009541583
公开号:
JP5517626B2
申请日:
2007.12.13
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 anti-body
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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