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Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
专利权人:
Bristol-Myers Squibb Company
发明人:
LIU, Chunjian,LEFTHERIS, Katerina,LIN, James
申请号:
ES06788851
公开号:
ES2578278T3
申请日:
2006.07.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of Formula (I) ** Formula ** an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, wherein: R1 is -NHCH3, -NHCH2CH3, -NHCH (CH3) 2, -NH (CH2) 2CH3 , -NH (CH) 2OCH3, -NH (CH2) 2N (CH3) 2, (R) -NH CH (CH3) CH2CH3, (S) -NHCH (CH3) CH2CH3, (R) -NHCH (CH3) CH2CH2OCH3, (S) -NHCH (CH3) CH2CH2OCH3, (R) - tetrahydrofuran-3-ylamino, (S) -tetrahydrofuran-3-ylamino, 4-morpholinoethylamino, 4-morpholinopropylamino, 1- piperidinoethylamino, 1-piperidinopropylamino or cyclopropylamino; R2 is hydrogen; and A is ** Formula ** in which R3 is fluorine in the ortho position; R6 is amino, amino substituted with 1 or 2 of the following: C1-C6 alkyl, hydroxy, C1-C6 alkoxy; R7 is hydrogen, C1-C6 alkyl, C1-C6 alkyl substituted with 1 to 4 hydroxy groups, C3-C8 cycloalkyl, phenyl, naphthyl, anthracenyl or monocyclic heterocycle with 3 to 7 members, saturated, partially unsaturated or fully unsaturated which It contains 1, 2, 3 or 4 heteroatoms selected from nitrogen atoms, oxygen atoms and / or sulfur atoms.Un compuesto de Fórmula (I)**Fórmula** un enantiómero, un diastereómero o una sal farmacéuticamente aceptable del mismo, en la que: R1 es -NHCH3, -NHCH2CH3, -NHCH(CH3)2, -NH(CH2)2CH3, -NH(CH)2OCH3, -NH(CH2)2N(CH3)2, (R)-NH CH(CH3)CH2CH3, (S)-NHCH(CH3)CH2CH3, (R)-NHCH(CH3)CH2CH2OCH3, (S)-NHCH(CH3)CH2CH2OCH3, (R)- tetrahidrofuran-3-ilamino, (S)-tetrahidrofuran-3-ilamino, 4-morfolinoetilamino, 4-morfolinopropilamino, 1- piperidinoetilamino, 1-piperidinopropilamino o ciclopropilamino; R2 es hidrógeno; y A es**Fórmula** en la que R3 es flúor en la posición orto; R6 es amino, amino sustituido con 1 o 2 de los siguientes: alquilo C1-C6, hidroxi, alcoxi C1-C6; R7 es hidrógeno, alquilo C1-C6, alquilo C1-C6 sustituido con de 1 a 4 grupos hidroxi, cicloalquilo C3-C8, fenilo, naftilo, antracenilo o heterociclo monocíclico con de 3 a 7 miembros, saturado, parcialmente insaturado o totalmente insaturado que contiene 1, 2, 3 o 4 heteroátomos seleccionados entre átomos d
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