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PHARMACEUTICAL COMPOUNDS
专利权人:
REVIRAL LIMITED
发明人:
James GOOD
申请号:
US16955568
公开号:
US20200316030A1
申请日:
2018.12.21
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Benzimidazole derivatives of formula (I): (Formula (I)) wherein: R1 is —;(CH2)m—;R7, (Formula (II)) or (Formula (III)); R2 is H, halo, —;(CH2)m—;NH2, —;(CH2)n—;C(═;NH)—;NH2 or —;(CH2)n—;NH—;(CH2)m—;NHR9; R3 is H, F or Cl; each of R4, R5 and R6 is independently H or F; R7 is C1-C6 alkyl, CF3, —;SO2R11, —;NH—;(CH2)2—;(NH)r—;R8, —;NH—;CH(R8R9) or a group of the following formula (A): (Formula (A)): W is —;(CH2)m, —;CH2—;O—;CH2—;, —;CH2—;S—;CH2—;, —;(CH2)r—;S(O)2—;CH2—; or —;(CH2)r—;NR8—;CH2—;; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R is H, —;SO2R11, —;SO2CF3, —;COR11, —;C(O)OR11, —;CON(R9)2 or —;(CH2)nSO2R11; R9 is H or C1-C6 alkyl, each R9 being the same or different when two are present; R10 is —;SO2R11, —;SO2CF3, —;COR11, —;CON(R9)2 or —;(CH2)nSO2R11; and R11 is C1-C6 alkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
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