A syringe (1) with high safety in use, comprising a syringe body (2) adapted to accommodate slidingly a plunger (3), the syringe body (2) having a protruding end that is adapted to allow the mating of a base end (5) of a needle (6), means (8) for removing the needle being provided which are interposed between the syringe body (2) and the base end (5) of the needle (6), the needle removal means (8) being adapted to be moved in a rotary direction for removal of the needle (6) and/or of the cap (7) of the needle.
