(57)< Abstract > Continual manufacturing method for the microsphere production which does not generate the problem of foaming, can acquire small granularity. The medicine and the polymer which are included in distributed phase with continual phase were injected continually in the emulsification container of high strength. The emulsion of distributed phase necessity do, is formed the disposal for foaming at effective high strength to the quick solidification of the distributed phase polymer at continual phase by mixture.発泡の問題を発生させない、小さな粒度が獲得できるミクロスフェア製造のための連続製法。分散相に含まれる薬剤及びポリマーは連続相と共に高い強度の乳化容器に連続的に注入された。分散相のエマルジョンは発泡に対する処置を必要とせずに、分散相ポリマーの急速な凝固に効果的な高い強度での混合により連続相で形成される。