BUSCH, BRETT,FLATT, BRENTON T.,GU, XIAO-HUI,MARTIN, RICHARD,MOHAN, RAJU,WANG, TIE-LIN,WU, JASON H.
申请号：
CA2555279
公开号：
CA2555279C
申请日:
2004.12.01
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Compounds for use in pharmaceutical compositions and methods for modulatingthe activity of nuclear receptors are provided. In particular, compounds foruse in compositions and methods for modulating the farnesoid X receptor,and/or orphan nuclear receptors, are provided.: formula (I) or apharmaceutically acceptable derivative thereof； wherein: R1 is -C(J)OR14, -C(J)SR14 and -C(J)N(R15)R16, J is O, S or NR17, R2 is hydrogen, halo oroptionally substituted alkyl； R3 is -C(O)R9, R4, R5, R6 and R7 and R8 are asdescribed in the claims.
