Thomas Børglum Kjeldsen;Tina Møller Tagmose;János Tibor Kodra;Peter Madsen;Thomas Hoeg-Jensen;Patrick William Garibay;Palle Jakobsen;Dorte Xenia Gram
发明人:
Peter Madsen,Thomas Børglum Kjeldsen,Thomas Hoeg-Jensen,Tina Møller Tagmose,Palle Jakobsen,János Tibor Kodra,Patrick William Garibay,Dorte Xenia Gram
申请号：
US12673516
公开号：
US09150633B2
申请日:
2008.08.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
An acylated insulin analogue wherein the insulin analogue comprises a lysine residue connected C-terminally to the A21 amino acid residue or a peptide residue of up to 4 amino acid residues comprising a lysine residue which peptide residue is connected C-terminally to the A21 amino acid residue, characterized in that an acyl moiety comprising an alkylene glycol moiety is attached to the lysine residue in the A22 position or attached to a lysine residue present in the peptide residue that is attached to the C terminal end of the A21 amino acid residue and wherein there is only one lysine (K, Lys) in the insulin analogue, can conveniently be administered pulmonary.
