Systems and methods for deoxygenating ophthalmic fluid are disclosed. The systems include an infusion system having a valve having an inlet in fluid communication with a source of gas, a first outlet in fluid communication with a container of ophthalmic fluid, and a second outlet in fluid communication with an infusion line of the system. The valve directs gas into the fluid disposed in the container to deoxygenate the fluid, and the deoxygenated fluid is then injected into the eye.
