Fundación para la Investigación Biomédica del Hospital Universitario 12 de Octubre;Universidad Complutense De Madrid
发明人:
申请号：
EP18382005.9
公开号：
EP3508270A1
申请日:
2018.01.09
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention provides sustained release polymeric nanocapsules capable of releasing proteases such as collagenase with a controlled kinetic and a prolonged and sustainable effect over time (up to more than 10 days). Additionally, these nanocapsules protect the housed protease, preferably collagenase, against external aggressions maintaining its catalytic activity. In this way, this invention overcomes the currents problems associated with collagenase administration using a precise combination of monomers and cross-linkers, as described in the claims that allow the formation of degradable polymeric nanocapsules with collagenase embedded within. These capsules provide a sustained release of the housed enzyme thus providing a therapeutic improvement in comparison to current therapies thus decreasing the need for repeated injections or high collagenase doses.
