The method broken out there is provided herein the plasma kallikrein antibody for being bound to active blood plasma kallikrein and using the Antybody therapy and prevention hereditary angioedema, this method can relate to the first treatment phase and the second optional treatment phase.Additionally provide the method using this Antybody therapy hereditary angioedema, the method is related to giving the antibody of single dose into the subject for having undergone previous HAE treatments, if subject undergoes HAE breaking-outs after single dose, the same antibody of multi-dose is then given.