COMPOSITIONS AND METHODS FOR EFFICACIOUS AND SAFE DELIVERY OF SIRNA USING SPECIFIC CHITOSAN BASED NANOCOMPLEXES

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专利权人:

发明人:

MERZOUKI ABDERRAZZAK,BUSCHMANN MICHAEL D

申请号：

IN3768/KOLNP/2013

公开号：

IN2013KN03768A

申请日:

2013.12.19

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly the composition contains a nucleic acid and a specific chitosan that has the following physico chemical properties: a number average molecular weight between 5 kDa and 200 kDa a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/