使用特異性的基於殼聚糖的納米複合物用於有效並安全遞送SIRNA的組合物和方法

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专利权人:

POLYVALOR S.E.C.

发明人:

MERZOUKI, ABDERRAZZAK,BUSCHMANN, MICHAEL D.

申请号：

HK14112843.8

公开号：

HK1199215A

申请日:

2014.12.23

申请国别(地区):

HK

年份:

2015

代理人:

摘要：

There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly, the composition contains a nucleic acid and a specific chitosan that has the following physico-chemical properties: a number-average molecular weight between 5 kDa and 200 kDa, a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/