Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
Calienni, John Vincent,Gong, Baoqing,Kapa, Prasad Koteswara,Chen, Guang-Pei,Saxena, Vishal
申请号：
NZ74660811
公开号：
NZ746608A
申请日:
2011.11.09
申请国别(地区):
NZ
年份:
2020
代理人:
摘要：
Disclosed is crystalline ribociclib succinate (N,N-dimethyl-7-cyclopentyl-2-(5-(piperazin-1-yl)-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-carboxamide mono-succinic acid salt) and intermediates for the synthesis of ribociclib. Also disclosed is a pharmaceutical composition comprising: (a) a therapeutically effective amount of the salt and at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient for the treatment of diseases such as cancers which responds to inhibition of cyclin dependent kinase activity.
