Refers to a compound of formula I or a pharmaceutically acceptable Salt thereof, where R1 is carbociclilo C4 C6 optionally substituted R2 and R3 is optionally substituted aryl or heteroaryl alkyl R4 is optionally substituted aryl or heteroaryl, among others a ring is not ar Omatico C4 C6, which has 0 - 1 heteroatoms.Preferred compounds are (S) - N - (1 - (2-chlorophenyl) - 2 - ((4 - difluorociclohexil) amino] - 2-oxoethyl) - N - (3-fluorophenyl) - 5 - oxopirrolidina - 2 - carboxamide, (S) - N - ((S) - 1 - (2-chlorophenyl) - 2 - (3,3 - difluorociclobutilamino) - 2-oxoethyl) - N - (3-fluorophenyl) - 5-oxo-1 - (thiazol-4-yl) - 2 - pyrrolidine carboxamide, among others. It also relates to a Pharmaceutical composition that is useful for the treatment of cancer.SE REFIERE A UN COMPUESTO DE FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE: R1 ES CARBOCICLILO C4-C6 OPCIONALMENTE SUSTITUIDO R2 Y R3 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS R4 ES ALQUILO, ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS A ES UN ANILLO NO AROMATICO C4-C6, QUE TIENE 0-1 HETEROATOMOS. SON COMPUESTOS PREFERIDOS (S)-N-(1-(2-CLOROFENIL)-2-((4,4-DIFLUOROCICLOHEXIL)AMINO)-2-OXOETIL)-N-(3-FLUOROFENIL)-5-OXOPIRROLIDINA-2-CARBOXAMIDA, (S)-N-((S)-1-(2-CLOROFENIL)-2-(3,3-DIFLUOROCICLOBUTILAMINO)-2-OXOETIL)-N-(3-FLUOROFENIL)-5-OXO-1-(TIAZOL-4-IL)PIRROLIDINA-2-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE CANCER.
